Relation between Beta-2-glycoprotein I and hepatitis B virus surface antigen.

Author: Pujun GAO ¹ ; Yanjun GUO ; Like QU ; Tong SHI ; Hongyan ZHANG ; Chun'e DONG ; Hanyi YANG
Author Information

1. Department of Internal Medicine, the First Affiliated Hospital, Norman Bethune University of Medical Sciences, Changchun 130021, China.
Publication Type:Journal Article
MeSH: Binding Sites; Biotinylation; Enzyme-Linked Immunosorbent Assay; methods; Glycoproteins; isolation & purification; metabolism; Hepatitis B Surface Antigens; metabolism; Hepatitis B virus; chemistry; metabolism; Humans; beta 2-Glycoprotein I
From: Chinese Journal of Hepatology 2002;10(1):31-33
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo clarify the binding character between Beta-2-glycoprotein I (Beta-2-GPI) and HBsAg.
METHODSBeta-2-GPI was purified from human plasma and labelled with biotin. Solid phase enzyme linked absorbance assay was used to investigate its binding with HBsAg.
RESULTSBiotinylated Beta-2-GPI was found to bind HBsAg and the reaction could be inhibited by excess unlabelled Beta-2-GPI.
CONCLUSIONSBeta-2-GPI may play a role in hepatitis B virus infection.