Relation between Beta-2-glycoprotein I and hepatitis B virus surface antigen.
- Author:
Pujun GAO
1
;
Yanjun GUO
;
Like QU
;
Tong SHI
;
Hongyan ZHANG
;
Chun'e DONG
;
Hanyi YANG
Author Information
- Publication Type:Journal Article
- MeSH: Binding Sites; Biotinylation; Enzyme-Linked Immunosorbent Assay; methods; Glycoproteins; isolation & purification; metabolism; Hepatitis B Surface Antigens; metabolism; Hepatitis B virus; chemistry; metabolism; Humans; beta 2-Glycoprotein I
- From: Chinese Journal of Hepatology 2002;10(1):31-33
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo clarify the binding character between Beta-2-glycoprotein I (Beta-2-GPI) and HBsAg.
METHODSBeta-2-GPI was purified from human plasma and labelled with biotin. Solid phase enzyme linked absorbance assay was used to investigate its binding with HBsAg.
RESULTSBiotinylated Beta-2-GPI was found to bind HBsAg and the reaction could be inhibited by excess unlabelled Beta-2-GPI.
CONCLUSIONSBeta-2-GPI may play a role in hepatitis B virus infection.