Identifying Polymorphisms in IL-31 and Their Association with Susceptibility to Asthma.
- Author:
Ji In YU
1
;
Weon Cheol HAN
;
Ki Jung YUN
;
Hyung Bae MOON
;
Gyung Jae OH
;
Soo Cheon CHAE
Author Information
1. Department of Pathology, Wonkwang University School of Medicine, Iksan, Korea. chaesc@wku.ac.kr
- Publication Type:Original Article
- Keywords:
IL-31;
Haplotypes;
Polymorphism;
Asthma;
Immunoglobulin E
- MeSH:
Asthma;
Gene Frequency;
Genotype;
Haplotypes;
Humans;
Immunoglobulin E;
Inflammation;
Interleukins;
Polymorphism, Single Nucleotide
- From:Korean Journal of Pathology
2012;46(2):162-168
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Interleukin 31 (IL-31) is a T helper type 2 effector cytokine that plays an important role in the pathogenesis of atopic and allergic diseases. IL-31 may be involved in promoting allergic inflammation and in inducing airway epithelial responses such as allergic asthma. METHODS: Single-base extension analysis was used to detect the genotypes of IL-31 single nucleotide polymorphisms (SNPs), and we compared the genotype and allele frequencies of the IL-31 SNPs between patients with asthma and healthy controls. RESULTS: There were no significant differences in the genotype and allele frequencies of the IL-31 SNPs between patients with asthma and healthy controls. Furthermore we compared the genotype and allele frequencies of IL-31 SNPs between patients with atopic asthma, those with non-atopic asthma and healthy controls. This showed that the SNPs were not associated with the susceptibility to atopic asthma. There were no significant differences in the haplotype frequencies of IL-31 SNPs between patients with asthma and healthy controls. In patients with asthma, the IL-31 SNPs were significantly correlated with total serum levels of IgE (p=0.035). CONCLUSIONS: Our results indicate that, the IL-31 SNPs may be associated with IgE production in patients with asthma.
