Application of ultrasound-guided percutaneous radiofrequency ablation in treatment of liver cancer.
- Author:
Xiao-yan XIE
1
;
Ming-de LÜ
;
Xiao-yu YIN
;
Jun-wei CHEN
;
Quan SHEN
;
Hui-xiong XU
;
Pei HUANG
;
Jie-fu HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma, Hepatocellular; diagnostic imaging; surgery; Catheter Ablation; methods; Female; Humans; Liver Neoplasms; diagnostic imaging; surgery; Male; Middle Aged; Temperature; Ultrasonography, Interventional
- From: Chinese Journal of Surgery 2003;41(1):23-26
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the therapeutic efficacy and its influencing factors of ultrasound-guided percutaneous radiofrequency ablation (PRFA) in the treatment of liver carcinoma.
METHODSWith a temperature-controlled multi-electrode needle, ultrasound-guided PRFA was employed to treat forty-seven patients with 67 tumor nodules, with a diameter of 2.6 +/- 1.1 cm (1.0 - 5.5 cm).
RESULTSA complete ablation (CA) rate of 80.6% was achieved in the present series, with a CA rate of 91.7% in the tumors < or = 3 cm in diameter, 75.0% in tumors from 3.1 to 4.0 cm, and 14.3% in tumors > 4 cm. The CA rate was significantly greater in tumors with a temperature rising up to 70 degrees C within the initial 2 minutes at ablation as compared with that longer than 2 minutes (P < 0.05). A markedly higher CA rate was obtained in tumors with an ablation-maintaining temperature of over 80 degrees C than that between 70 degrees C and 80 degrees C (P < 0.01). All patients were followed up with a mean time of 11.3 months. The local recurrence rate was 9.3% (5/54), and 1-year survival rate was 82.1%. Eighteen patients (38.3%) had a distant recurrence.
CONCLUSIONSThe tumor size, temperature-rising time and ablation-maintaining temperature represented the important factors affecting the therapeutic efficacy of PRFA.
