Expression and significance of clusterin in normal prostate, benign prostate hyperplasia and prostate cancer.
- Author:
Li-qun ZHOU
1
;
Xue-zhen YANG
;
Li ZENG
;
Li-li LIANG
;
Xin-yu YANG
;
Liang REN
;
Lee CHUNG
;
Zhi-wen ZHANG
;
Yan-qun NA
;
Fang-liu GU
;
Ying-lu GUO
Author Information
- Publication Type:Journal Article
- MeSH: Apoptosis; Clusterin; metabolism; physiology; Female; Humans; Immunohistochemistry; Male; Prostate; metabolism; Prostatic Hyperplasia; metabolism; Prostatic Neoplasms; metabolism; pathology; physiopathology
- From: Chinese Journal of Surgery 2003;41(2):93-95
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression and significance of Clusterin in normal prostate, benign prostate hyperplasia (BPH) and prostate cancer.
METHODSClusterin expression in samples of 12 normal prostate, 15 BPH, and 56 prostate cancer were studied by immunohistochemical stain.
RESULTSOf 83 cases, 67 are positive or weak positive (81%). The rate of positive or weak positive for normal prostate, BPH and prostate cancer was 17% (2/12), 73% (11/15), and 96% (54/56) respectively. The expression level of Clusterin in prostate cancer was much higher than in normal prostate (t = 8.82, P < 0.01). BPH (t = 7.63, P < 0.01) was related positively with pathological grade (r = 0.649, P < 0.01) and stage (r = 0.609, P < 0.01) of prostate cancer.
CONCLUSIONClusterin may play an important role in the biological characteristics of prostate cancer by the anti-apoptosis pathway.
