Roles of non-coding RNA in pancreatic islet development and functioning.
10.3881/j.issn.1000-503X.2014.06.025
- Author:
Yuan-Yuan JIN
1
;
Jian-Feng WANG
1
;
Xue-Jun WANG
2
;
Li YUAN
3
Author Information
1. Laboratory Center for Basic Medical Sciences,Nanjing Medical University,Nanjing 210029,China.
2. Laboratory Center for Basic Medical Sciences,Nanjing Medical University,Nanjing 210029,China
3. Department of Biochemistry and Molecular Biology, Nanjing Medical University,Nanjing 210029,China.
- Publication Type:Journal Article
- MeSH:
Cell Differentiation;
Diabetes Mellitus;
Gene Expression;
physiology;
Gene Expression Profiling;
Gene Expression Regulation, Developmental;
Humans;
Insulin;
Insulin-Secreting Cells;
Islets of Langerhans;
growth & development;
metabolism;
MicroRNAs;
RNA, Untranslated;
metabolism
- From:
Acta Academiae Medicinae Sinicae
2014;36(6):691-696
- CountryChina
- Language:English
-
Abstract:
Non-coding RNA is a kind of non-coding protein RNA which is widely present in most of the organisms. Non-coding RNA plays key roles in the embryonic development,cell fate determination,and growth control in the living organisms. MicroRNA and long non-coding RNA involve in differentiation of endocrine cell,insulin gene expression and secretion,and insulin resistance,which are closely associated with diabetes.
