Advances in the proinflammatory effects of visfatin and its relationship with diabetic kidney disease.
10.3881/j.issn.1000-503X.2015.02.019
- Author:
Liang-yan ZHANG
1
;
Xue-mei LI
1
Author Information
1. Department of Nephrology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
- Publication Type:Journal Article
- MeSH:
Cytokines;
Diabetic Nephropathies;
Humans;
Nicotinamide Phosphoribosyltransferase
- From:
Acta Academiae Medicinae Sinicae
2015;37(2):246-252
- CountryChina
- Language:English
-
Abstract:
Visfatin, also known as the pre-B-cell colony enhancing factor, is a new member of the adipocytokines. It serves as a nicotinamide phosphoribosyltransferase in cells. Visfatin has complex biological functions and may be involved in the pathogenesis of diabetic kidney disease; it may contribute to the chronic inflammatory status at systemic and renal levels and thus aggravate renal injury. Further research on visfatin will provide new insights in the treatment of diabetic kidney disease. This article reviews the recent advances in the proinflammatory effects of visfatin and its relationship with diabetic kidney disease.
