Association between KLKB1 Polymorphisms and Pulmonary Thromboembolism.

Min-ne Wang; Xiao-mao XU; Zhen-guo Zhai; Liang Sun; Bao-min Fang; Xiao Fei; Jian Guo

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Association between KLKB1 Polymorphisms and Pulmonary Thromboembolism.

Author: Min-Ne WANG ^{1
,

2} ; Xiao-Mao XU ³ ; Zhen-Guo ZHAI ⁴ ; Liang SUN ⁵ ; Bao-Min FANG ⁵ ; Xiao FEI ⁵ ; Jian GUO ⁵
Author Information

1. Graduate School,CAMS and PUMC,Beijing 100730,China
2. National Center for Clinical Laboratories,Beijing Hospital,Beijing 100730,China.
3. Department of Respiratory and Critical Care Medicine,Beijing Hospital,Bejing 100730,China.
4. Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders,Beijing Institute of Respiratory Medicine, Department of Respiratory Disease,Chaoyang Hospital,Capital University of Medical Sciences,Beijing 100020,China.
5. Beijing Institute of Geriatric Medicine,Beijing Hospital,Beijing 100730,China.
Publication Type:Journal Article
MeSH: Alleles; Case-Control Studies; Chi-Square Distribution; Genotype; Haplotypes; Humans; Kallikreins; Polymorphism, Single Nucleotide; Pulmonary Embolism
From: Acta Academiae Medicinae Sinicae 2015;37(3):274-278
CountryChina
Language:English
Abstract:
OBJECTIVETo investigate the potential correlation between the single nucleotide polymorphisms (SNPs) in the KLKB1 region and pulmonary thromboembolism(PTE) in a Chinese Han population.
METHODSIn this case-control study, 95 patients with confirmed PTE were enrolled as the PTE group and 90 healthy subjects as the control group. The genotypes, alleles, and haplotypes of the SNPs were analyzed with PLINK 1.07 and Haploview 4.2 software using chi-square test and Logistic regression analysis. SNPs were further analyzed under three genetic models (additive, dominant, and recessive).
RESULTSThe distribution of rs3733402 in KLKB1 gene showed significant difference between PTE group and control group (P=0.041). The distributions of GTG haplotypes consisted of rs2292423, rs4253325,and rs3733402 in KLKB1 gene were also significantly different between PTE group and control group(P=0.040).
CONCLUSIONThe rs3733402 locus variation in KLKB1 gene is associated with PTE in Chinese Han people.