Regulatory Effects of Long Non-coding RNA on Tumorigenesis.
10.3881/j.issn.1000-503X.2015.03.023
- Author:
Wen-Jun LIAO
1
;
Yi-Lei MAO
1
Author Information
1. Department of Liver Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
- Publication Type:Journal Article
- MeSH:
Cell Transformation, Neoplastic;
Epigenesis, Genetic;
Gene Expression Regulation, Neoplastic;
Humans;
RNA, Long Noncoding
- From:
Acta Academiae Medicinae Sinicae
2015;37(3):358-363
- CountryChina
- Language:English
-
Abstract:
Long non-coding RNAs(LncRNA)may play a key role in tumorigenesis by regulating gene expression and intervening transcription. Recent studies have demonstrated that a series of patterns including protein modification,chromosomal reconstruction,regulation of target gene expression,transcription intervention,epigenetic modification,and natural antisense transcript are involved in this process. This article reviews recent research advances in this aspect with an attempt to better understand the role of LncRNA in tumorigenesis.
