Progress of burn research in metabolism and nutrition in China.
- Author:
Shi-liang WANG
1
Author Information
1. Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, the Third Military Medical University, Chongqing 400038, P.R. China.
- Publication Type:Journal Article
- MeSH:
Adult;
Animals;
Burns;
metabolism;
therapy;
Humans;
Nutritional Support;
Proteins;
metabolism;
Rats;
Thermogenesis
- From:
Chinese Journal of Burns
2008;24(5):396-399
- CountryChina
- Language:Chinese
-
Abstract:
The achievements of burn metabolism and nutrition in China are briefly presented. Advance a new theory "Enterogenous Hypermetabolism". Develop a formula to calculate calorie needs in Chinese burn adults. Put forward new ideas on glucose absorption, neo glycogenesis, insulin resistance, and the use of hypoglycemic agent after burn injury. Observe the variation of plasma level of free aminoacids, investigate the changes and mechanisms of 26S proteasome and 19S regulator in skeletal muscle of burn trauma, and the clinical application and its mechanism of glutamine and arginine. Introduce the approach of (13)C NMR spectroscopy to investigate the alterations of hepatic anabolism functions in severely burned rats. Offer supplying the suitable dosage of vitamin A, C, E and microelement of zinc, copper, ferrum for burn patients. Carry out serial studies of early enteral and parenteral nutrition, and compare enteral nutrition with parenteral nutrition. Early enteral nutrition with synbiotics might be beneficial to the controlling of burn infection. Both glucagon like peptide-2 (GLP-2) and intestinal trefoil factor (ITF) exhibit protective effect on intestinal mucosa in minimizing injury and protecting barrier function. The choice of suitable opportunity to use rhGH (growth hormone) is investigated. In addition, advance the view points of ischemia and anoxia in metabolism, anti-inflammatory immune and nutrition.
