Study on the distribution of nodularin in tissues and cell level in mice.
- Author:
Zhanying ZHANG
1
;
Shunzhang YU
;
Chuanwei CHEN
;
Guorong WEI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Nucleus; metabolism; Female; Kidney; metabolism; Liver; metabolism; Male; Marine Toxins; pharmacokinetics; Mice; Peptides, Cyclic; pharmacokinetics
- From: Chinese Journal of Preventive Medicine 2002;36(2):100-102
- CountryChina
- Language:English
-
Abstract:
OBJECTIVESTo study the tissue distribution of nodularin in mice and the cellular location of nodularin in the target organs.
METHODSThe nodularin was labeled with radioactive isotope (125)I and then was given to mice via oral, intraperitoneal and intravenous administration. The distribution of nodularin in target organs and the cellular location of nodularin were studied by radioisotope and autoradiography techniques.
RESULTSThe radioisotope study results showed that nodularin was mainly distributed in the kidney and liver in mice. Further autoradiography study indicated that nodularin was distributed in the renal cell nuclei and liver cell nuclei.
CONCLUSIONThe kidney and liver are the two main target organs for nodularin in mice.
