Radiosynthesis and preliminary evaluation of 5-(11Cmethyloxy)-L-tryptophan as PET tumor imaging.
- Author:
Shan-zhen HE
;
Shu-xia WANG
;
Kong-zhen HU
;
Bao-guo YAO
;
Gang-hua TANG
- Publication Type:Journal Article
- MeSH:
Amino Acids;
Animals;
Neoplasms;
diagnostic imaging;
Positron-Emission Tomography;
Radioactive Tracers;
Tissue Distribution;
Tryptophan;
analogs & derivatives
- From:
Acta Pharmaceutica Sinica
2015;50(5):565-568
- CountryChina
- Language:Chinese
-
Abstract:
The PET tracer 5-([11C]methyloxy)-L-tryptophan (5-(11)CMTP) was prepared by nucleophilic fluorination and alkylation reaction via a two-step procedure in order to develop specific tumor probe. The biodistribution and microPET imaging of 5-(11)CMTP were executed. The results unveiled that the overall radiochemical yield with no decay correction was (14.6 ±7.2) %, the radiochemical purity was more than 95% and high uptake and long retention time of 5-(11)CMTP in liver, kidney and blood were observed but low uptake in brain and muscle were found, furthermore, high uptake of 5-(11)CMTP in tumor tissue was observed. It seems that 5-(11)CMTP will be a potential amino acid tracer for tumors imaging with PET.
