Novel hybrids of (phenylsulfonyl)furoxan and N-benzyl matrinol as anti-hepatocellular carcinoma agents.
- Author:
Li-qin HE
;
Qi YANG
;
Ya-xian WU
;
Xiao-shan WANG
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents;
pharmacology;
Carcinoma, Hepatocellular;
Fluorouracil;
Hep G2 Cells;
Humans;
Liver Neoplasms;
Oxadiazoles;
pharmacology
- From:
Acta Pharmaceutica Sinica
2015;50(5):574-578
- CountryChina
- Language:Chinese
-
Abstract:
N-Benzyl matrinol was obtained by hydrolysis, benzylation and reduction reaction from matrine. A series of hybrids (8a-8n) from (phenylsulfonyl)furoxan and N-benzyl matrinol were synthesized and biologically evaluated as anti-hepatocellular carcinoma agents. All target compounds were evaluated for anti-proliferative activity against human hepatocellular Bel-7402, SMMC-7721, Bel-7404, and HepG2 cells in vitro by MTT method. The results indicated that all of these compounds had potent anti-proliferative activity which were more potent than their parent compound and 5-FU, especially 8a-8h and 8j showed the strongest anti-HCC HepG2 cell activity with IC50 values of 0.12-0.93 μmol x L(-1).
