Chemical constituents from Morus notabilis and their cytotoxic effect.
- Author:
Pan ZHEN
;
Gang NI
;
Xiao-guang CHEN
;
Ruo-yun CHEN
;
Han-ze YANG
;
De-quan YU
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents, Phytogenic;
chemistry;
Benzofurans;
chemistry;
Flavonoids;
chemistry;
Hep G2 Cells;
Humans;
Inhibitory Concentration 50;
Morus;
chemistry;
Plant Extracts;
chemistry;
Terpenes;
chemistry
- From:
Acta Pharmaceutica Sinica
2015;50(5):579-582
- CountryChina
- Language:Chinese
-
Abstract:
Une new flavonoids named as notabilisin K (1), together with four known compounds, morusin (2), mulberrofuran A (3), neocyclomorusin (4) and mornigrol F (5) are separated from 95% ethanol extracts of the twigs of Morus notabilis. Compounds 2-5 are separated from this plant for the first time. Notabilisin I, notabilisin J exhibits certain effect against cells of HCT-116, HepG2 and A2780 with IC50 values ranging from 1.47 μmol x L(-1) to 5.46 μmol x L(-1). Morusin exhibits strong effect against five kinds of human cancer cells (BGC823, A2780, HCT-116, HepG2 and NCI-H1650) with IC50 values ranging from 0.74 μmol x L(-1) to 1.58 μmol x L(-1).
