Research progress in the study of protective effect of tanshinone IIA on cerebral ischemic stroke.
- Author:
De-chuan LI
;
Xiu-qi BAO
;
Hua SUN
;
Dan ZHANG
- Publication Type:Journal Article
- MeSH:
Antioxidants;
therapeutic use;
Apoptosis;
Diterpenes, Abietane;
therapeutic use;
Drugs, Chinese Herbal;
therapeutic use;
Humans;
Salvia miltiorrhiza;
chemistry;
Stroke;
drug therapy
- From:
Acta Pharmaceutica Sinica
2015;50(6):635-639
- CountryChina
- Language:Chinese
-
Abstract:
Danshen is one of the traditional Chinese herbal medicines and nas a long history or being used clinically in the treatment of cardiovascular and cerebrovascular conditions such as coronary heart disease and angina pectoris. Tanshinone IIA is a derivative of phenanthrene-quinone isolated from Danshen. It has been reported to be the major bioactive compound of Danshen and has diverse biological effects. Recent studies demonstrated that tanshinone IIA had neuroprotective effects on experimental ischemic stroke through its antiinflammatory, anti-oxidant, anti-apoptosis effects and its inhibitory effect on excitatory amino acid toxicity. In this review, we summarized all the recent progresses on the protective effect of tanshinone IIA on cerebral ischemic stroke. Hopefully, this article will throw some light on further study and application of tanshinone IIA.
