Synthesis and antioxidative activity of flavone derivatives containing 1,2,4-triazole structure.
- Author:
Zhi-fang DUAN
;
Ling SHAO
;
Sai-nan LI
- Publication Type:Journal Article
- MeSH:
Cinnamates;
chemistry;
Flavones;
chemical synthesis;
chemistry;
Flavonoids;
chemistry;
Free Radical Scavengers;
chemical synthesis;
chemistry;
Triazoles;
chemistry
- From:
Acta Pharmaceutica Sinica
2015;50(7):861-867
- CountryChina
- Language:Chinese
-
Abstract:
Using bioactive compounds 7-hydroxy flavone, salicylaldehyde, cinnamic acid and 4-amino-5- mercapto-1,2,4-triazoles as starting materials, three new types of flavone derivatives containing 1,2,4-triazole structure were synthesized via different step reactions. These new compounds were characterized by 1IHNMR, ESI-MS, IR and elemental analysis. Their scavenging effects on the superoxide radical (O2·-), hydroxyl radical (·OH), DPPH · radical and their total reduction activities were tested. The results showed that all of the compounds possessed some antioxidative activity at the concentration of 0.5 mg · mL(-1), but the scavenging ability of the target compounds was lower than that of the standard compound Vc.
