Progress in the biomarker discovery for drug-induced liver injury.
- Author:
Lei-yan HE
;
Yao-xue GUO
;
Chun LI
;
Ye DENG
;
Qi-zhi ZHANG
;
Wen-xing PENG
- Publication Type:Journal Article
- MeSH:
Biomarkers;
blood;
urine;
Chemical and Drug Induced Liver Injury;
diagnosis;
Humans;
Sensitivity and Specificity
- From:
Acta Pharmaceutica Sinica
2015;50(8):959-965
- CountryChina
- Language:Chinese
-
Abstract:
The leading cause of drug withdrawal from market and clinical trials failure is drug-induced liver injury (DILI). Varying clinical, histological and laboratory features of DILI, as well as undefined underlying mechanisms, hinder patients to be diagnosed in the early-stage of the disease and receive effective treatments. Conventional indicators, like serum transaminases and bilirubin, have inevitable limitations referring to sensitive prediction and specific detection of DILI. In order to reduce the occurrence of DILI, researchers have attempted to discover potential biomarkers with higher specificity and sensitivity from blood and urine in recent years. This article aims to review recent advances in biomarkers of DILI.
