Gray relational analysis for the effect of nano-drug features on drug absorption.
- Author:
Jie YU
;
Mao-sheng ZHENG
;
Chao-ni XIAO
;
Xiao-hui ZHENG
- Publication Type:Journal Article
- MeSH:
Drug Carriers;
chemistry;
Humans;
Macrophages;
cytology;
Nanoparticles;
chemistry;
Particle Size;
Phagocytosis
- From:
Acta Pharmaceutica Sinica
2015;50(9):1096-1100
- CountryChina
- Language:Chinese
-
Abstract:
Gray relational analysis is employed to analyze the effects of nano-drug features on phagocytosis of macrophages, including zeta potential, shape factor and scale size of drug particle, the correlation among such factors and macrophage cell is calculated. The results showed that the internalization processe is affected significantly by the zeta potential of the drug in the process of phagocytosis of macrophages, followed by the impact particle shape, and the effect of particle scale behaves relatively small.
