Pharmacokinetics of salvianolic acid A after single intravenous administration in Rhesus monkey.
- Author:
Jun-ke SONG
;
Wen ZHANG
;
Wei-ku ZHANG
;
Zhang-ying FENG
;
Tao XIE
;
Guan-Hua DU
- Publication Type:Journal Article
- MeSH:
Administration, Intravenous;
Animals;
Caffeic Acids;
pharmacokinetics;
Chromatography, Liquid;
Drugs, Chinese Herbal;
pharmacokinetics;
Lactates;
pharmacokinetics;
Macaca mulatta;
Mass Spectrometry;
Plant Roots;
chemistry;
Salvia miltiorrhiza;
chemistry
- From:
Acta Pharmaceutica Sinica
2015;50(9):1142-1147
- CountryChina
- Language:Chinese
-
Abstract:
Salvianolic acid A (Sal A) is one of the most effective compounds isolated from the root of Salvia miltiorrhiza. Up to now, several studies regarding the pharmacokinetic profiles of Sal A have been reported, however there is no such study reported in monkeys, the species which is more similar to human. The aim of this study is to develop a LC-MS method for the determination of Sal A in monkey plasma and apply it to the pharmacokinetic studies of monkeys. After single intravenous administration of Sal A, the plasma concentration-time curves were observed and the main pharmacokinetic parameters were calculated. The plasma concentration at 2 min (C2 (min)) values were (28.343 ± 6.426), (45.679 ± 12.301) and (113.293 ± 24.360) mg x L(-1) for Rhesus monkeys treated with Sal A at 2.5, 5 and 10 mg x kg(-1). The area under the concentration-time curve (AUC(0-∞)) values were (3.316 ± 0.871), (5.754 ± 2.150) and (13.761 ± 2.825) μg x L(-1) x h, respectively. Furthermore, this method was improved and applied to the simultaneous determination of Sal A, Sal B and Sal C, which provided useful information for preclinical studies and clinical trials of Sal A, Sal B and Sal C.
