Effects of yijing recipe on sperm apoptosis and mitochondrial membrane potential in patients with idiopathic oligoathenoteratospermia.
- Author:
Yong-Zheng JIAO
1
;
Ling-Dong MENG
;
Wei-Guo MA
;
Jin-Ming JIA
Author Information
- Publication Type:Clinical Trial
- MeSH: Adult; Apoptosis; drug effects; Asthenozoospermia; drug therapy; pathology; physiopathology; Drugs, Chinese Herbal; therapeutic use; Humans; Infertility, Male; drug therapy; pathology; physiopathology; Male; Membrane Potential, Mitochondrial; drug effects; Oligospermia; drug therapy; pathology; physiopathology; Phytotherapy; Semen Analysis; Sperm Motility; Spermatozoa
- From: National Journal of Andrology 2012;18(11):1045-1049
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of Yijing Recipe on sperm apoptosis and mitochondrial membrane potential (MMP) in patients with idiopathic oligoathenoteratospermia.
METHODSUsing the self-control method, we examined sperm apoptosis and MMP in 30 patients with oligoathenoteratospermia before and after treated with Yijing Recipe.
RESULTSThe rates of early sperm apoptosis (AV +/PI -) and MMP loss were significantly reduced after treatment as compared with pre-medication ([2.86 +/- 1.47]% vs [4.26 +/- 2.79]% and [21.77 +/- 13.46]% vs [41.73 +/- 20.30]%, P<0.05). No statistically significant difference was observed in the sperm death rate (PI+) before and after treatment ([34.10 +/- 16.26]% vs [30.21 +/- 13.50]%, P>0.05).
CONCLUSIONYijing Recipe can reduce early sperm apoptosis and improve MMP, which may be one of the mechanisms underlying its efficacy on oligoathenoteratospermia.
