Cell-free RNA in human seminal plasma: characteristics and potential application.
- Author:
Li-Ping WANG
1
;
Hong-Gang LI
Author Information
1. Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Infertility, Male;
diagnosis;
genetics;
Male;
MicroRNAs;
genetics;
RNA;
analysis;
Semen;
chemistry
- From:
National Journal of Andrology
2012;18(10):936-939
- CountryChina
- Language:Chinese
-
Abstract:
Cell-free RNAs (cfRNAs), including mRNA and microRNA, are transcripts existing outside cells. These extracellular RNAs have been detected in many kinds of human body fluids and reported as promising noninvasive biomarkers for disease diagnosis and research. Recent studies discovered the presence of cfRNAs in human seminal plasma and revealed its general characteristics. Cell-free seminal RNA has been proposed as a novel noninvasive biomarker for male infertility and forensic identification. This review focuses on the general characteristics, current application, and perspective of cfRNAs.
