Susceptibility to prostate cancer in Han Chinese: single nucleotide polymorphism analysis of 1 667 cases.
- Author:
Yong CUI
1
;
Yi-Chao SHI
;
Hua SHEN
;
You-Zhang FAN
;
Wen-Zhou CAO
;
Jian-Jun XIE
;
Huai-Qing SU
;
Qiang SHAO
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Asian Continental Ancestry Group; genetics; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Prostatic Neoplasms; epidemiology; genetics; Risk Factors
- From: National Journal of Andrology 2012;18(12):1069-1074
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEProstate cancer (PCa) has the highest incidence among male malignancies in Western industrialized countries and, as a most common malignant disease in urology, its incidence has been increasing in recent years in Chinese men. This study was to investigate the risk loci associated with PCa susceptibility in Han Chinese by analyzing single nucleotide polymorphisms (SNP).
METHODSWe collected peripheral blood samples from 1 667 PCa patients and 1 525 healthy men, and detected 40 loci associated with PCa susceptibility by analyzing SNPs using Sequenom technology.
RESULTSOf the 40 known loci, 16 were confirmed to be significantly associated with PCa susceptibility (P < 0.05). The loci 1, 2 and 5 at 8q24, 10q11 and 22q13.2 also contributed to PCa susceptibility in different ethnic groups.
CONCLUSIONPCa susceptibility is obviously associated with the risk loci rs1465618, rs721048, rs12621278, rs7679673, rs12653946, rs339331, rs1512268, rs10086908, rs16901979, rs1447295, rs10993994, rs10896449, rs902774, rs9600079, rs11649743 and rs5759167 in Chinese Han population.
