Activities of the fragments of semenogelin I: an update.
- Author:
Chen HU
1
;
Hui ZHAO
Author Information
1. Department of Urology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China. jyhuchen@126.com
- Publication Type:Journal Article
- MeSH:
Anti-Bacterial Agents;
Humans;
Male;
Semen;
drug effects;
Seminal Vesicle Secretory Proteins;
genetics;
physiology;
Spermatozoa;
drug effects
- From:
National Journal of Andrology
2013;19(2):169-172
- CountryChina
- Language:Chinese
-
Abstract:
Semenogelin I (Sg I) and the fragments of peptides hydrolyzed from Sg I by prostate-specific antigen have multiple biological activities. There exists a controversy over the inhibitory effect of the key fragment on sperm motility. This article focuses on the sperm-inhibiting and antibacterial activities of the fragments of Sg I-derived peptides and illustrates the supposition concerning the most controversial aspect. A deeper insight into the action mechanisms of Sg I-derived peptides may help improve the methods of sperm screening and provide a new perspective in the management of asthenozoospermia and urinary tract infection.
