Signaling pathway of meiosis induced by retinoic acid during spermatogenesis.
- Author:
Ke WANG
1
;
Ying-Ji WU
Author Information
1. College of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia 010021, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Humans;
Male;
Meiosis;
Signal Transduction;
Spermatogenesis;
Tretinoin;
metabolism
- From:
National Journal of Andrology
2013;19(2):173-177
- CountryChina
- Language:Chinese
-
Abstract:
Retinoic acid (RA) is an oxidative metabolite of vitamin A (retinol, ROH) and plays an important role in the spermatogenesis (as in meiosis) of mammals. In mammalian testes, RA, in combination with its retinoic acid receptor (RAR), regulates the expressions of related target genes in various types of cells at different times. It activates meiosis by up-regulating the expressions of the genes that promote meiosis and down-regulate those that inhibit it during spermatogenesis in a specific stage. The results of researches on mammalian spermatogenesis have a great application value in reproductive biology, developmental biology, and reproductive engineering. Therefore, it is of considerable significance to study the signaling pathway of RA-induced meiosis during mammalian spermatogenesis. This article presents an introduction of the RA signal transduction system and its action mechanisms, as well as an overview on the signaling pathway of RA-activated meiosis during spermatogenesis.
