Sperm DNA integrity of infertile males with hepatitis B virus infection.
- Author:
Tian-Qin DENG
1
;
Yong-Han HUANG
;
Jin-Yi ZHEN
;
Jian-Tang LU
;
Ying-Chang LI
;
Xing-Yin TAN
;
Xiong-Chun LIU
;
Jian-Bo RUAN
;
Hai-Bin ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Case-Control Studies; Chromatin; DNA; genetics; DNA Damage; Hepatitis B; pathology; Hepatitis B virus; Humans; Infertility, Male; genetics; virology; Male; Sperm Count; Spermatozoa; pathology; Young Adult
- From: National Journal of Andrology 2013;19(1):72-76
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate sperm DNA integrity in male infertility patients with hepatitis B virus (HBV) infection.
METHODSThis study included 90 infertile men with HBV infection (group A), 82 infertile men without HBV infection (group B) and 70 normal fertile men (group C). We detected sperm DNA integrity among the subjects, including DNA fragmentation index (DFI) and high DNA stainability (HDS), by sperm chromatin structure assay (SCSA), and compared them among the three groups.
RESULTSDFI was higher in group A ([28.17 +/- 13.06]%) than in B ([26.64 +/- 9.79]%) and C ([15.67 +/- 4.73]%), significantly higher in A and B than in C (P < 0.05) but with no significant difference between A and B (P > 0.05). HDS was higher in group A ([10.83 +/- 5.601]%) than in B ([9.04 +/- 3.48]%) and C ([8.04-2.25]%), with significant difference between A and C (P < 0.05).
CONCLUSIONSperm DNA integrity of infertile males is significantly different from that of normal fertile men, and infertility with HBV infection further impairs sperm DNA, which is manifested by abnormal sperm nuclear maturity.
