DAZL gene polymorphisms and astheno-teratozoospermia.
- Author:
Lu-Wei YE
1
;
Qing-Feng YU
;
Xue-Xi YANG
;
Jing-Ping LI
;
Xiao-Qiang WU
;
Yong-Hai ZHANG
;
Xiang-Ming MAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Asian Continental Ancestry Group; genetics; Case-Control Studies; Genotype; Humans; Infertility, Male; genetics; Male; Oligospermia; genetics; Polymorphism, Single Nucleotide; RNA-Binding Proteins; genetics
- From: National Journal of Andrology 2013;19(4):311-314
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between single nucleotide polymorphism (SNP) of the DZAL gene in infertile Han Chinese males with astheno-teratozoospermia.
METHODSWe collected semen samples from 173 infertile Han Chinese men with astheno-teratozoospermia (case group) and 175 age-matched normal male volunteers (control group) for semen routine and morphological analyses. We obtained genomic DNA, genotyped the polymorphisms of the DAZL gene A260G and A386G via the Sequenom MassARRAY system, and compared the frequencies of the genotypes between the case and control groups.
RESULTSThe AA nucleotide variant was found in the A260G and A386G polymorphisms of the DZAL gene in both the cases and controls, but the heterozygous AG variant in neither.
CONCLUSIONThe A260G and A386G polymorphisms of the DAZL gene are not correlated with astheno-teratozoospermia-induced male infertility in the Han Chinese population, and therefore could not be considered as molecular markers of male infertility.
