Expressions of SIgA and alpha 1-AR in benign prostatic hyperplasia combined with chronic prostatitis and their implications.
- Author:
Wei-Jun GAO
1
;
Yang-Min WANG
;
Chang-Hai WANG
;
Xu-Kai YANG
;
Lin WAN
;
Wei-Ping LI
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Chronic Disease; Humans; Immunoglobulin A, Secretory; metabolism; Male; Middle Aged; Prostate; metabolism; pathology; Prostatic Hyperplasia; complications; metabolism; pathology; Prostatitis; complications; metabolism; pathology; Receptors, Androgen; metabolism
- From: National Journal of Andrology 2013;19(4):315-320
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the expressions of SIgA and alpha l-AR in benign prostatic hyperplasia (BPH) complicated by chronic prostatitis (CP) and their implications.
METHODSAccording to the preoperative findings of expressed prostatic secretion (EPS), transrectal prostate ultrasonography, prostate-specific antigen (PSA), international prostate symptom score (IPSS), clinical symptoms, chronic pelvic pain syndrome (CPPS) and postoperative histopathology, 62 cases of BPH pathologically confirmed after transurethral plasma kinetic resection of the prostate (PKRP) were divided into a BPH group (n = 32) and a BPH + CP group (n = 30). The expressions of SIgA and alpha 1-AR in the prostate tissue were determined by immunohistochemistry and PT-PCR.
RESULTSOf the 62 cases, 30 were found to be BPH + CP, and the other 32 to be BPH. The expressions of SIgA and alpha1-AR were significantly higher in the BPH + CP than in the BPH group (0.380 8 +/- 0.144 3 vs 0.295 4 +/- 0.008 4 and 0.440 5 +/- 0.104 1 vs 0.383 2 +/- 0.013 6, P < 0.05).
CONCLUSIONThe upregulated expressions of SIgA and alpha1-AR expression in BPH complicated by CP suggest a certain association between CP and BPH, and that inflammation may be a pathogenic factor of BPH and correlate with its pathological development.
