Association of 5-lipoxygenase expression and clinicopathological factors in colorectal carcinoma.
- Author:
Yue-chun LI
1
;
Dong-xia WANG
;
Cai-shi LI
;
Zhen-peng YE
;
Zhi-ming WU
;
Jian-hua CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Arachidonate 5-Lipoxygenase; metabolism; Colorectal Neoplasms; enzymology; pathology; Female; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging
- From: Chinese Journal of Gastrointestinal Surgery 2013;16(9):895-897
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo examine the association of 5-lipoxygenase (5-LOX) expression with clinicopathological factors in colorectal cancer.
METHODSImmunohistochemical stain was used to detect the 5-LOX expression in 52 resected specimens of colorectal cancer. The association between 5-LOX expression and clinicopathological factors was examined.
RESULTSThe positive rate of 5-LOX expression in 52 specimens of colorectal carcinoma was 73.1% (38/52). In 41 colorectal cancer specimens with lymph node metastasis, the positive rate of 5-LOX expression was higher than that in the specimens without metastasis (87.8% vs. 18.2%, P<0.05). The positive rate of 5-LOX expression in the specimens with deep infiltration (T3 and T4) was higher than that in the specimens with superficial infiltration (T1 and T2) (81.1% vs. 53.3%, P<0.05). The positive rate of 5-LOX expression in TNM stage III and IIII cancer was higher than that in stage I and II (79.5% vs. 53.8%, P<0.05). The positive rate of 5-LOX expression in cancers of poor differentiation and non-differentiation adenocarcinoma was higher than that of well and moderately differentiated cancer (100% vs. 50.0%, P<0.05). There were no significant differences of 5-LOX expression with tumor size,vascular invasion and peritoneal dissemination.
CONCLUSION5-LOX expression in colorectal carcinoma is closely associated with lymph node metastasis, infiltration depth, differentiation degree and TNM stage.
