Aromatic compounds from an aqueous extract of "ban lan gen" and their antiviral activities.
10.1016/j.apsb.2016.09.004
- Author:
Yufeng LIU
1
,
2
;
Minghua CHEN
1
;
Qinglan GUO
3
;
Yuhuan LI
4
;
Jiandong JIANG
1
;
Jiangong SHI
3
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2. Department of Pharmacy, Jining Medical University, Jining 272067, China.
3. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
4. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- Keywords:
Antiviral activity;
Aromatic metabolite;
Cruciferae;
Isatis indigotica
- From:
Acta Pharmaceutica Sinica B
2017;7(2):179-184
- CountryChina
- Language:English
-
Abstract:
A pair of new diphenyl glycerol ether enantiomers (-)-and (+)-and two new methyl benzamidobenzoatesand, named (-)-()- and (+)-()-isatindigotrioic acid [(-)-and (+)-] and isatindigoticamides A () and B (), respectively, were isolated from an aqueous decoction of the roots of(ban lan gen). Their structures were elucidated by spectroscopic data analysis including 2D NMR experiments. The absolute configurations of (-)-and (+)-were assigned based on the CD exciton chirality method. Compoundsandexhibited antiviral activities against HSV-1 with ICvalues of 4.87 and 25.87 μmol/L, respectively. Compoundwas also found active against Coxsackie virus B3 and LPS-induced NO production.
