Indole alkaloid sulfonic acids from an aqueous extract ofroots and their antiviral activity.
10.1016/j.apsb.2017.04.003
- Author:
Lingjie MENG
1
;
Qinglan GUO
1
;
Yufeng LIU
1
;
Minghua CHEN
1
;
Yuhuan LI
1
;
Jiandong JIANG
1
;
Jiangong SHI
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- Keywords:
Antiviral activity;
Cruciferae;
Indole alkaloid sulfonic acids;
Isatibis indosulfonic acids;
Isatindosulfonic acids;
Isatis indigotica
- From:
Acta Pharmaceutica Sinica B
2017;7(3):334-341
- CountryChina
- Language:English
-
Abstract:
Six new indole alkaloid sulfonic acids (-), together with two analogues (and) that were previously reported as synthetic products, were isolated from an aqueous extract of theroot. Their structures including the absolute configurations were determined by spectroscopic data analysis, combined with enzyme hydrolysis and comparison of experimental circular dichroism and calculated electronic circular dichroism spectra. In the preliminary assay, compoundsandshowed antiviral activity against Coxsackie virus B3 and influenza virus A/Hanfang/359/95 (H3N2), respectively.
