Flavanols from thevar.and their hypoglycemic and hypolipidemic activities.
10.1016/j.apsb.2016.12.007
- Author:
Xin WANG
1
;
Quan LIU
1
;
Hongbo ZHU
1
;
Hongqing WANG
1
;
Jie KANG
1
;
Zhufang SHEN
1
;
Ruoyun CHEN
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- Keywords:
Camellia sinensis var. assamica;
Flavanol;
Hypoglycemic;
Hypolipidemic;
Pu-erh tea
- From:
Acta Pharmaceutica Sinica B
2017;7(3):342-346
- CountryChina
- Language:English
-
Abstract:
-Glucosidase and lipase inhibitors play important roles in the treatment of hyperglycaemia and dyslipidemia. To identify novel naturally occurring inhibitors, a bioactivity-guided phytochemical research was performed on the pu-erh tea. One new flavanol, named (-)-epicatechin-3---coumarate (), andknown analogs (-) were isolated from the aqueous extract of the pu-erh tea. Their structures were determined by spectroscopic and chemical methods. Furthermore, the water extract of pu-erh tea and its fractions exhibited inhibitory activities against-glucosidases and lipases; compoundshowed moderate inhibitory effect against sucrase with an ICvalue of 32.5 μmol/L and significant inhibitory effect against maltase with an ICvalue of 1.3 μmol/L. Compounds,,anddisplayed moderate activity against a lipase with ICvalues of 16.0, 13.6, 19.8, and 13.3 μmol/L, respectively.
