Chinese herbal medicine compound Yi-Zhi-Hao pellet inhibits replication of influenza virus infection through activation of heme oxygenase-1.
10.1016/j.apsb.2017.05.006
- Author:
Jinqiu YIN
1
;
Linlin MA
2
;
Huiqiang WANG
1
;
Haiyan YAN
1
;
Jin HU
1
;
Wen JIANG
3
;
Yuhuan LI
1
Author Information
1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
2. School of Medical Technology, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China.
3. Department of Pharmacy, The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi 830002, China.
- Publication Type:Journal Article
- Keywords:
Hemagglutinin;
Heme oxygenase 1;
Influenza A virus;
NF-κB;
Nrf2;
TMC
- From:
Acta Pharmaceutica Sinica B
2017;7(6):630-637
- CountryChina
- Language:English
-
Abstract:
As a leading cause of respiratory disease, influenza A virus (IAV) presents a pandemic threat in annual seasonal outbreaks. Given the limitation of existing anti-influenza therapies, there remains to be a requirement for new drugs. Compound Yi-Zhi-Hao pellet (CYZH) is a famous traditional Chinese medicine (TCM) used in the clinic, whose formula has been recorded into treat common cold. In this study, we found that CYZH exhibited a broad-spectrum anti-influenza activity and inhibited the expression of viral RNA and proteins. Mechanistically, CYZH had no inhibitory activities against viral protein hemagglutinin and IAV RNA-dependent RNA polymerase. Instead, it induced activation of erythroid 2-related factor 2 (Nrf2) and nuclear factor kappa B (NF-B), which subsequently upregulated heme oxygenase-1 (HO-1) expression. Also, CYZH protected cells from oxidative damage induced by reactive oxygen series. In conclusions, CYZH inhibits IAV replication, at least partly by activating expression of the Nrf2/HO-1 pathway.
