8,4'-Oxyneolignane glucosides from an aqueous extract of "ban lan gen" (root) and their absolute configurations.
10.1016/j.apsb.2017.09.006
- Author:
Lingjie MENG
1
;
Qinglan GUO
1
;
Yufeng LIU
1
;
Jiangong SHI
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- Keywords:
8,4′-Oxyneolignane;
Absolute configuration;
Cotton effect;
Cruciferae;
Isatioxyneolignosides A−F;
Isatis indigotica;
Threo/erythro Isomers;
ΔδC8-C7 value
- From:
Acta Pharmaceutica Sinica B
2017;7(6):638-646
- CountryChina
- Language:English
-
Abstract:
Three pairs of glycosidic 8,4'-oxyneolignane diastereoisomers, named isatioxyneolignosides A-F (-), were isolated from an aqueous extract ofroots. Their structures and absolute configurations were elucidated by comprehensive spectroscopic data analysis and enzyme hydrolysis. The validity of Δvalues to distinguishandaryl glycerol units and Cotton effects at 235±5 nm to determine absolute configurations at C-8 in-and their aglycones (-) are discussed.
