Immunohistochemical study on expression of MMP-2 and MMP-9 in irritation fibroma, oral leukoplakia and oral squamous cell carcinoma.
- Author:
Moon Key KIM
1
;
Eun Ha LEE
;
Jin KIM
;
Eui Woong LEE
;
In Ho CHA
Author Information
1. Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University, Korea.
- Publication Type:Original Article
- MeSH:
Apoptosis;
Basement Membrane;
Carcinoma, Squamous Cell*;
Cell Differentiation;
Collagenases;
Connective Tissue;
Epithelium;
Fibroma*;
Leukoplakia, Oral*;
Mucous Membrane;
Neoplasm Metastasis
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2006;32(4):352-359
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
MMP-2 and MMP-9, type IV collagenases which degrade basement membrane, have been known to play important roles in invasion and metastasis of tumor cells, In addition, they seem to be involved in cell differentiation, apoptosis, angiogenesis and immunity, etc. We immunohistochemically examined epithelial and stromal expressions of MMP-2 and MMP-9 in irritation fibroma, oral leukoplakia, and oral squamous cell carcinoma (OSCC) and have some results as follows: 1. Irritation fibromas, oral leukoplakias and OSCCs mostly showed increased expression of MMP-2 and MMP-9 in the epithelium and connective tissue compared with normal mucosa. 2. There was a significant difference in the epithelial expression of MMP-2 and MMP-9 between irritation fibroma and oral leukoplakia. 3. There was a significant difference in the epithelial and stromal expression of MMP-2 and MMP-9 between irritation fibroma and OSCC. 4. There was a significant difference in the stromal expression of MMP-9 between oral leukoplakia and OSCC. We concluded that rritation fibroma, oral leukoplakia and OSCC have somewhat different characteristics of MMP-2 and MMP-9 expressions, which perhaps result from different pathogenesis.
