The effect of pulsed electromagnetic fields on beta-TCP graft in rabbit cranial bone defect.
- Author:
Sang Woo KIM
1
;
Kyung Gyun HWANG
;
Byung Sup LIM
;
Chang Joo PARK
;
Il Hyuk CHUNG
;
Seung Sam PAIK
;
Kwang Sup SHIM
Author Information
1. Department of Dentistry/Oral and Maxillofacial Surgery, College of Medicine Hanyang University, Korea.
- Publication Type:Original Article
- Keywords:
Pulsed electromagnetic field (PEMF);
Autogenous bone;
beta-tricalcium phosphate (beta-TCP);
Osteogenesis
- MeSH:
Animals;
Bone Regeneration;
Electromagnetic Fields*;
Magnets*;
Osteogenesis;
Rabbits;
Sutures;
Transforming Growth Factor beta1;
Transplants*;
Vascular Endothelial Growth Factor A
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2006;32(4):360-373
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The purpose of this research was to investigate whether pulsed electromagnetic field (PEMF) stimulation applied to the rabbit cranial defects grafted with beta-tricalcium phosphate (beta-TCP) could affect the new bone formation. With 16 New Zealand white rabbits under the same condition, bilateral calvarial bone defects were formed around the sagittal suture line. The defect on the left side was grafted with beta-TCP, while on the right side was grafted by harvested autogenous bone. PEMF was applied to 8 rabbits for 8 hours per day. The bony specimen were divided into 3 groups, the group 1 was autogenous bone grafted specimen, the group 2 was beta-TCP grafted with PEMF, and the group 3 was beta-TCP grafted without PEMF. We investigated the bone regeneration and growth factor expression at 2, 4, 6, and 8 weeks. As a result, BMP 2 was expressed in the group 1 from 2 weeks, the group 2 from 4 weeks, and the group 3 from 6 weeks. BMP 4 was expressed in the group 1 from 2 weeks, in the group 2 and the group 3 from 4 weeks. 4. There was no significant difference in expression pattern of BMP 7, PDGF, VEGF, and TGF-beta1 during grafted bone regeneration in group 1, 2, and 3. According to our results, PEMF stimulation could be effective on the new bome formation in animal study, and have a feasibility of clinical use.
