Acute Response to Co-60 Total Body Irradiation (TBI) With 600 cgy at 3 Different Does Rates in the Mice.
- Author:
Cheol Hoon KANG
1
;
Sung Kyu KUM
;
Sei One SHIN
;
Myung Se KIM
Author Information
1. Department of Therapeutic Radiology, College of Medicine, Yeungnam University, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
Total body irradiation;
Dose rate;
Acute effects
- MeSH:
Animals;
Leukocyte Count;
Leukopenia;
Mice*;
Weight Loss;
Whole-Body Irradiation*
- From:Journal of the Korean Society for Therapeutic Radiology
1990;8(2):151-154
- CountryRepublic of Korea
- Language:English
-
Abstract:
The acute effects of variable dos rates to total body irradiation (TBI) were investigated with 600 cgy of single exposure in the mice as a preclinical model. Total 80 mice (ICR) were used. Twenty of which served as controls, receiving no irradiation. All irradiated mice showed a universal decline in their weight and white blood cell count. The degree of weight loss and leukopenia were similar at 3 different dos rate but slightly prominent with 15 cgy/minute group. The degree of recovery among the groups showed no dose rate dependence. Our results suggest that TBI with 15 cgy/minute may be applicable for clinical therapy with careful evaluation of patient's condition.
