A research of endothelial cell-targeted therapy for cure of hypertrophic scar.
- Author:
Rui SHEN
1
;
Tian-zeng LI
;
Shao-hai QI
;
Hui-zhen LIANG
;
Ying-bin XU
;
Ju-lin XIE
;
Yi-fang WU
;
Xiang-sheng FENG
;
Yong-jun DU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apoptosis; Burns; complications; Cicatrix, Hypertrophic; chemically induced; therapy; Collagen Type I; Collagen Type III; Disease Models, Animal; Endothelial Cells; Feasibility Studies; Neovascularization, Pathologic; etiology; Vascular Endothelial Growth Factor A
- From: Chinese Journal of Plastic Surgery 2003;19(4):254-257
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the feasibility of endothelial cell-targeted therapy to cure post-burn hypertrophic scar.
METHODSA hypertrophic scar animal model was made. Intralesional injecting of VEGF monoclonal antibody was performed for three weeks. The changes of scar in volume and morphology were observed.
RESULTS1. The volume of scar decreased. 2. The number of the capillary, the amount of collagen I and collagen III decreased. 3. Transmission electron microscope examinations demonstrated many dead or apoptotic fibroblasts and endothelial cells. Fibrocytes were seen relatively common.
CONCLUSIONVEGF induces the growth and development of hypertrophic scar in that it induces excessive and uncontrollable angiogenesis, which favors excessive collagen synthesis. Endothelial cell-targeted therapy may be a promising method to cure post-burn hypertrophic scar.
