Effects of vacuum-assisted closure (VAC) on the expressions of MMP-1, 2, 13 in human granulation wound.
- Author:
Bing SHI
1
;
Shao-zong CHEN
;
Ping ZHANG
;
Jin-qing LI
Author Information
- Publication Type:Journal Article
- MeSH: Collagen; metabolism; Humans; Matrix Metalloproteinase 1; metabolism; Matrix Metalloproteinase 13; metabolism; Matrix Metalloproteinase 2; metabolism; Negative-Pressure Wound Therapy; Polymerase Chain Reaction; Time Factors; Wound Healing
- From: Chinese Journal of Plastic Surgery 2003;19(4):279-281
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the changes of metalloproteinases 1, 2, 13 in granulation wound after the treatment of vacuum-assisted closure (VAC).
METHODSThe chronic wounds in 5 patients were treated with VAC. The expressions of MMP-1, 2, 13 in the granulation tissues of the chronic wounds were determined and quantified using RT-PCR technique before and at 1, 4, 7 days after the treatment.
RESULTSThe MMP-1, 13 mRNA showed obvious decrease, with the steepest variation of MMP-13. The MMP-2 mRNA also showed a decreased tendency, though in an undulatory fashion.
CONCLUSIONVAC can promote healing of chronic wounds through depressing the expressions of MMP-1, 2, 13 mRNA and protein synthesis, depressing the degradations of collagen and gelatin.
