Effects of shuangshen tongguan (SSTG) on TNF-alpha, ICAM-1 during myocardial ischemia-reperfusion injury.
- Author:
Xiao HAN
1
;
Jian-xun LIU
;
Xiao-bin MA
;
Yang-hui WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drug Combinations; Drugs, Chinese Herbal; pharmacology; Intercellular Adhesion Molecule-1; blood; Myocardial Infarction; blood; pathology; Myocardial Reperfusion Injury; blood; pathology; Myocardium; pathology; Panax; chemistry; Plants, Medicinal; chemistry; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; chemistry; Tumor Necrosis Factor-alpha; metabolism
- From: China Journal of Chinese Materia Medica 2004;29(11):1073-1075
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effects of SSTG on infarction size and tumor necrosis factor-alpha (TNF-alpha), intercellular adhesion molecular-1 (ICAM-1) levels in serum during reperfusion injury of acute myocardial ischemia.
METHODAnterior descending branch of coronary artery was ligated and released to create myocardial ischemia-reperfusion injury. The size and weight of infarction area and the contents of TNF-alpha, IGAM-1 in serum were assayed by N-BT staining and ELISA respectively.
RESULTThe size and weight of infarct area and the contents of TNF-alpha, ICAM-1 in serum were significantly increased compared with the normal group and were obviously decreased after being treated with SSIG.
CONCLUSIONIschemia-reperfusion stimulated the secretion of TNF-alpha and ICAM-1, which play an important role in ischemia-reperfusion injury. SSTG might protect myocardium from ischemia-reperfusion injury by suppressing over-secretion of TNF-alpha and ICAM-1 and reducing the size and weight of infarction area.
