Effects of Astragalus and saponins of Panax notoginseng on MMP-9 in patients with type 2 diabetic macroangiopathy.
- Author:
Kuan-zhi LIU
1
;
Jing-bo LI
;
Hai-li LU
;
Jin-kun WEN
;
Mei HAN
Author Information
- Publication Type:Clinical Trial
- MeSH: Aged; Astragalus membranaceus; chemistry; Diabetes Mellitus, Type 2; blood; drug therapy; enzymology; Diabetic Angiopathies; blood; drug therapy; enzymology; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Female; Ginsenosides; isolation & purification; therapeutic use; Humans; Hypolipidemic Agents; therapeutic use; Lipids; blood; Male; Matrix Metalloproteinase 9; blood; Middle Aged; Panax; chemistry; Phytotherapy; Plants, Medicinal; chemistry; Simvastatin; therapeutic use
- From: China Journal of Chinese Materia Medica 2004;29(3):264-266
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the role and mechanism of Astragalus (AS) and saponins of Panax notoginseng (PNS) in treating type 2 diabetic macroangiopathy.
METHOD94 patients with type 2 diabetic macroangiopathy were divided into two groups randomly: group treated with Simvastatin and group treated with AS and PNS, compared with 40 healthy control subjects. Serum level of MMP-9 and lipid in patients and healthy subjects were measured before and after treatment.
RESULTThe serum levels of MMP-9, TG, TC, LDL-C, VLDL-C in patients with type 2 diabetic macroangiopathy were improved, while the levels of HDL-C were decreased. Like Simvastatin AS and PNS had the function of reducing MMP-9 and accommodating lipid metabolism.
CONCLUSIONBesides accommodating lipid metabolism, AS and PNS can also reduce the level of serum MMP-9 soas to treat type 2 diabetic macroangiopathy.
