Studies on mechanism of antiasthmatic and anti-inflammatory actions of CDCA.
- Author:
Pei-feng LI
1
;
Hong GUAN
;
Hong-xia ZHAO
;
Qin SI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Asthmatic Agents; pharmacology; Anti-Inflammatory Agents, Non-Steroidal; pharmacology; Chenodeoxycholic Acid; pharmacology; Cyclic AMP; metabolism; Dinoprostone; metabolism; Female; Lung; metabolism; Male; Materia Medica; pharmacology; Mice; Nitric Oxide; metabolism; Rats; Rats, Wistar; Trachea; metabolism
- From: China Journal of Chinese Materia Medica 2004;29(4):349-352
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe antiasthmatic and anti-inflammatory actions mechanisms of CDCA.
METHODThe content of NO was determined by method of nitroreductase chromatometry in serum and trachea tissue. The content of cAMP was analysed by method of competitive protein-binding assay. The content of PGE2 was determined by method of ultraviolet spectrophotometry.
RESULTCDCA significantly decreased the content of NO of serum and trachea tissue in mice. CDCA increased greatly the content of cAMP of trachea tissue in rats. CDCA significantly decreased the content of PGE2 of trachea and lung tissue in mice.
CONCLUSIONMechanisms of antiasthmatic and anti-inflammatory actions of CDCA are related to increasing the content of cAMP in trachea tissue and decreasing the constituent of NO and PGE2 in body.
