Effect of Spatholobus suberectus on the bone marrow cells and related cytokines of mice.
- Author:
Dong-hui CHEN
1
;
Xia LUO
;
Meng-yao YU
;
Yi-qing ZHAO
;
Yao-feng CHENG
;
Zhi-rong YANG
Author Information
- Publication Type:Journal Article
- MeSH: Anemia; pathology; Animals; Bone Marrow Cells; cytology; Cell Proliferation; drug effects; Colony-Stimulating Factors; metabolism; Drugs, Chinese Herbal; isolation & purification; pharmacology; Fabaceae; chemistry; Female; Male; Mice; Plant Stems; chemistry; Plants, Medicinal; chemistry
- From: China Journal of Chinese Materia Medica 2004;29(4):352-355
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of Spatholobus suberectus on proliferation and the hematonic mechanism.
METHODThe techniques of culture of hematopoietic cell and hematopoietic growth factor (HGF) assay were used.
RESULTSpatholobus suberectus could obviously promote the proliferation of bone marrow cells in healthy and anaemic mice. The culture media of spleen cell, macrophage, lung and skeletal muscle treated with S. suberectus had much stronger stimulating effects on hematopoietic cells.
CONCLUSIONS. suberectus may enhance hematopoiesis by directly or indirectly stimulating stroma cell in hematopoietic inductive microenvironment and muscle tissue to secrete some HGF (Epo, GM-CSF, IL, and MK-CSF). This is one of the biological mechanisms for hematonic effect of S. suberectus.
