Effect of qilong capsule on hemoreology in acute stress blood stasis rats.
- Author:
Yan WU
1
;
Jian-ning SUN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Astragalus membranaceus; chemistry; Blood Viscosity; drug effects; Capsules; Drug Combinations; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacology; Erythrocyte Aggregation; drug effects; Erythrocyte Deformability; drug effects; Hemorheology; drug effects; Hemostasis; drug effects; Male; Materia Medica; administration & dosage; isolation & purification; pharmacology; Oligochaeta; chemistry; Plants, Medicinal; chemistry; Rats; Rats, Wistar; Salvia miltiorrhiza; chemistry; Stress, Physiological; physiopathology
- From: China Journal of Chinese Materia Medica 2004;29(4):362-365
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the influence of Qilong capsule (QLC) on the hemoreology in acute stress blood stasis model rats.
METHODThe model of acute stress blood stasis rats were induced by putting the rats into ice-water between hyodermic epinephrine twice of 1 mg x kg(-1). With the models, the effect of QLC on hemoreology such as whole blood viscosity, whole blood reduction viscosity, plasma viscosity, haematocrit (Hct), erythrocyte deformation and erythrocyte aggregation were observed.
RESULTQLC 0.6, 0.3, 0.15 g x kg(-1) could significantly reduce the increase of whole blood viscosity at high-middle-low shear rate, reduce the whole blood reduction viscosity at middle-low shear rate, reduce Hct and erythrocyte aggregation, and increase the erythrocyte deformation in acute stress blood stasis rats (P < 0.05, P < 0.01, compared with vehicle). QLC 0.6, 0.3 g x kg(-1) could also reduce plasma viscosity (P < 0.05, P < 0.01, compared with vehicle).
CONCLUSIONQLC can significantly improve some indexes of hemoreology in acute stress blood stasis rats.
