Effects of L-tetrahydropalmatine on concentrations of neurotransmitter amino acids in mice with cerebral ischemia.
- Author:
Zhong-miao ZHANG
1
;
Xiao-xiang ZHENG
;
Bo JIANG
;
Quan ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Berberine Alkaloids; pharmacology; Brain; metabolism; Brain Ischemia; metabolism; Drugs, Chinese Herbal; pharmacology; Female; Ginkgo biloba; chemistry; Glutamic Acid; metabolism; Male; Mice; Mice, Inbred ICR; Neuroprotective Agents; pharmacology; Plants, Medicinal; chemistry; Stereoisomerism; gamma-Aminobutyric Acid; metabolism
- From: China Journal of Chinese Materia Medica 2004;29(4):371-373
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effects of L-tetrahydropalmatine (L-THP) on concentrations of neurotransmitter amino acids in mice with cerebral ischemia and to discuss the mechanisms of L-THP in tyreating cerebral ischemia.
METHODMice were randomly divided into six groups: control group, cerebral ischemia group, L-THP treated group (doses were 14, 28, 56 mg x kg(-1) respectively) and Ginkgo biloba extract treated group. Concentrations of Glu and GABA were determined by HPLC.
RESULTCompared with control group, Glu and GABA in mice with cerebral ischemia were much higher. The ratio of Glu/GABA increased significantly. L-THP markedly reduced the concentrations of Glu and the ratio of Glu/GABA in mice with cerebral ischemia.
CONCLUSIONDecrease in Glu concertration and ratio of Glu/GABA may be one of the mechanisms of L-THP in treating cerebral ischemia.
