Synthetical evaluation of promoting effect of some kinds of transdermal enhancers with grey relational cluster method.
- Author:
Hui WANG
1
;
Xin LI
;
Bi-lian XU
;
Wei-ming XU
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Cutaneous; Animals; Azepines; pharmacology; Bornanes; pharmacology; Cluster Analysis; Cnidium; chemistry; Diclofenac; administration & dosage; pharmacokinetics; Male; Menthol; pharmacology; Oils, Volatile; isolation & purification; pharmacology; Rabbits; Skin Absorption; drug effects
- From: China Journal of Chinese Materia Medica 2004;29(5):417-420
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESynthetical evaluation of promoting effect of some kinds of transdermal enhancers was carried through.
METHODDiclofenac sodium was used as model, and azone and l-menthol and synthetic borneol and olieic acid and essential oil from Cnidium monnieri were used as transdermal enhancers. Transdermal absorption experimentation of diclofenac sodium on the device of penetrating skins in vitro was done. Cumulation of permeation amount and penetrating rates and steady fluxes and lag times were observed, and grey relational cluster method was used to evaluate the promoting effect of some kinds of transdermal enhancers.
RESULTAs for promoting effect on diclofenac sodium, azone and l-menthol were the best, and synthetic borneol and olieic acid ranked behind.
CONCLUSIONGrey relational cluster method can evaluate promoting effect objectively and fairly.
