Study on the antioxidative effect of Safflor Yellow.
- Author:
Ming JIN
1
;
Jin-rong LI
;
Wei WU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antioxidants; isolation & purification; pharmacology; Carthamus tinctorius; chemistry; Chalcone; administration & dosage; analogs & derivatives; isolation & purification; pharmacology; Dose-Response Relationship, Drug; Flowers; chemistry; Free Radical Scavengers; pharmacology; Hydroxyl Radical; metabolism; Lipid Peroxidation; drug effects; Liver; metabolism; Male; Mice; Plants, Medicinal; chemistry; Rabbits
- From: China Journal of Chinese Materia Medica 2004;29(5):447-449
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the antioxidative effect of Safflor Yellow (SY).
METHODHydroxyl radical scavenge effect of SY was tested with 1,10-phenanthroline-Fe2+ oxidative assay. Lipid peroxidation of mouse liver suspension was measured with thiobarbituric acid colorimetry technique. Hemocytocatheresis was determined with colorimetry.
RESULTHydroxyl radical could be scavenged by 1.39 to 3.42 g x L(-1) SY dose dependently. Mouse liver suspension peroxidation was inhibited by 77.8 to 776.1 mg x L(-1) SY dosage dependently. Hemocytocatheresis was attenuated by 37.1 to 297.1 mg x L(-1) SY dose dependently.
CONCLUSIONSY is an antioxidative part of Carthamus tinctorius.
