Effect of association of Shiquandabu Tang with Hetaokun on liver and immunity of tumour mouse.
- Author:
Xu DU
1
;
Lu LIU
;
Ying-hua ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antineoplastic Agents, Phytogenic; pharmacology; Benzoquinones; isolation & purification; pharmacology; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Fruit; chemistry; Juglans; chemistry; Liver; pathology; Lymphocyte Activation; drug effects; Macrophages; immunology; Male; Mice; Mitochondria, Liver; drug effects; Mitochondrial Swelling; drug effects; Phagocytosis; drug effects; Plants, Medicinal; chemistry; Sarcoma 180; immunology; pathology
- From: China Journal of Chinese Materia Medica 2004;29(5):449-451
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo discuss the effect of the association of Shiquandabutang with Hetaokun on the protection to liver and immunity of tumor mouse S180.
METHODThrough the comparison between tumor transplanted and tumor cultured completely out of cell body, the effect was investigated, with Hetaokun singly used and Shiquandabutang associated with Hetaokun, on the level of SGPT, licking up function of monocyte macrophage, thymus index, spleen index and transform percentage of lymphocyte of the mouse S180. The scanning electron micrographs indicated the protective function of the association of Shiquandabutang with Hetaokun for liver.
RESULT12.5 mg x kg(-1) Hetaokun could obviously restrain the tumor when it was singly used at 73.1%, but it increased SGPT at the same time. The association of Shiquandabutang with Hetaokun could protect liver of the mouse S180. SGPT (P > 0.05) was compared with the common ones and the result showed that the association of shiquandabutang with Hetaokun could make K value increase (P > 0.01). Through the scanning electron micrographs, association of two medicines was found to change liver cells little and expansion of rough Neizhiwang was not found. Compared with the control group, the immunity of the two tumor mouse groups taking the medicine mentioned above was promoted obviously.
CONCLUSIONThe association of Shiquandabutang with Hetaokun can enhance the efficiency and decrease poison of them to body. With the promotion of immunity of the body, the efficiency is enhanced on the whole.
