Experimental study on protecting intestinal barrier function of Huoxiang Zhengqi soft capsule.
- Author:
Yi-chong XIE
1
;
Fang TANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Capsules; Drug Combinations; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacology; Female; Hindlimb; blood supply; Ileum; pathology; Intestinal Mucosa; pathology; ultrastructure; Ischemia; complications; Male; Mast Cells; drug effects; Mucus; drug effects; Plants, Medicinal; chemistry; Protective Agents; pharmacology; Rats; Rats, Wistar; Reperfusion Injury; pathology
- From: China Journal of Chinese Materia Medica 2004;29(5):456-458
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of Huoxiang Zhengqi soft capsule on protecting intestinal barrier.
METHODLower limb ischemic reperfusion model was induced in Wistar rats. The Chinese medicine groups were administered orally with Huoxiang Zhengqi soft capsule before inoculation respectively. The small intestinal histopathology and ultrastructural of rats were observed with optical microscope and electronic microscope respectively. Mucus was observed under AB-PAS staining, mast cells were studied under toluidine blue staining, and serum NO was determined.
RESULTAfter Lower limb ischemic reperfusion, the intestinal barrier function was severely damaged. Huoxiang Zhengqi soft capsule could significantly reduce the levels of the serum NO (P < 0.01).
CONCLUSIONHuoxiang Zhengqi soft capsule has apparent protective effect on the intestinal barrier function in lower limb ischemic reperfusion rats.
