Primary research of pharmacological effects of PEC on mice.
- Author:
Li-wei WANG
1
;
Xin-min LIU
;
Guang-hua LU
;
Nan-nan GAO
;
Pei-gen XIAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Behavior, Animal; drug effects; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Epimedium; chemistry; Fatigue; drug therapy; Hypoxia; drug therapy; Male; Memory Disorders; drug therapy; Mice; Panax; chemistry; Pentobarbital; pharmacology; Phytotherapy; Plants, Medicinal; chemistry; Schisandra; chemistry; Sleep; drug effects; Swimming
- From: China Journal of Chinese Materia Medica 2004;29(6):568-593
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study pharmacological effects of PEC (the oral liquid which consists of Panax quinquefolium, Epimedium brevicornum, Schisandra chinensis Bail and Cervus eplaphus) on mice.
METHODExperiments were carried out through swimming test, step-through, spontaneous activity and sleeping time.
RESULTWhen 5-10 mL x kg(-1) of PEC was given orally for 7 days, it could prolong swimming duration of mice in water tank, and increase the tolerant ability against oxygen-deficiency. PEC could also improve cognitive-deficiency induced by taking off sleep with force in mice after given orally for 7 days. The PEC could increase the spontaneous activity in mice, antagonize the inhabitation induced by Valium, and shorten the sleeping time caused by sodium pentobarbital.
CONCLUSIONPEC has strong potential neuro-pharmacological activities such as anti-fatigue, improving cognitive-deficiency in mice.
