Calcium pyrophosphate dihydrate crystal deposition disease: a clinicopathologic analysis of 20 cases.
- Author:
Hui-qiong FANG
1
;
Qi-ming LI
;
Yao-qu HUANG
;
Ji-si XING
;
Rong-jun MAO
;
Le XIE
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Chondrocalcinosis; diagnostic imaging; pathology; surgery; Female; Follow-Up Studies; Hip Joint; diagnostic imaging; pathology; surgery; Humans; Intervertebral Disc; diagnostic imaging; pathology; surgery; Knee Joint; diagnostic imaging; pathology; surgery; Magnetic Resonance Imaging; Male; Middle Aged; Retrospective Studies; Spinal Diseases; diagnostic imaging; pathology; surgery; Synovial Membrane; pathology; Tomography, X-Ray Computed
- From: Chinese Journal of Pathology 2012;41(12):828-832
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinicopathologic features of calcium pyrophosphate dihydrate crystal deposition disease (CPPD-CDD).
METHODSThe clinical and pathologic profiles were retrospectively analysed in 20 cases of CPPD-CDD.
RESULTSCPPD-CDD was far more common in women, most frequently involving joints, especially the knees and presenting with various arthrisis. Abnormally calcified and the articular damages were characteristic features by imageing. Histologically, multifocal indigo granular calcinosis was seen in synovium and sometimes appeared as needle-shaped or rhomboid crystals, which characterized the CPPD.
CONCLUSIONSThough clinical symptoms of CPPD are quite variable, the definite diagnosis can be made by the abnormal calcification and joint damage radiographically and the indigo CPPD crystals histopathologically.
