Comparison between Resectable Helicobacter pylori-Negative and -Positive Gastric Cancers.
- Author:
Hee Jin KIM
1
;
Nayoung KIM
;
Hyuk YOON
;
Yoon Jin CHOI
;
Ju Yup LEE
;
Yong Hwan KWON
;
Kichul YOON
;
Hyun Jin JO
;
Cheol Min SHIN
;
Young Soo PARK
;
Do Joong PARK
;
Hyung Ho KIM
;
Hye Seung LEE
;
Dong Ho LEE
Author Information
- Publication Type:Comparative Study ; Original Article ; Research Support, Non-U.S. Gov't
- Keywords: Helicobacter pylori; Stomach neoplasms; Negative infection; Atrophy
- MeSH: Antibodies, Bacterial/analysis; Female; Helicobacter Infections/*complications/epidemiology/microbiology; *Helicobacter pylori; Humans; Male; Middle Aged; Prevalence; Prospective Studies; Republic of Korea/epidemiology; Stomach Neoplasms/epidemiology/*microbiology/*pathology/surgery; Urease/analysis
- From:Gut and Liver 2016;10(2):212-219
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Controversy exists regarding the characteristics of Helicobacter pylori infection-negative gastric cancer (HPIN-GC). The aim of this study was to evaluate clinicopathologic features of HPIN-GC compared to H. pylori infection-positive gastric cancer (HPIP-GC) using a comprehensive analysis that included genetic and environmental factors. METHODS: H. pylori infection status of 705 resectable gastric cancer patients was determined by the rapid urease test, testing for anti-H. pylori antibodies, histologic analysis and culture of gastric cancer tissue samples, and history of H. pylori eradication. HPIN-GC was defined as gastric cancer that was negative for H. pylori infection based on all five methods and that had no evidence of atrophy in histology or serology. RESULTS: The prevalence of HPIN-GC was 4% (28/705). No significant differences with respect to age, sex, smoking, drinking, family history of gastric cancer or obesity were observed between the two groups. HPIN-GC tumors were marginally more likely to involve the cardia (14.3% for HPIN-GC vs 5.3% for HPIP-GC, p=0.068). The Lauren classification, histology, and TNM stage did not differ according to H. pylori infection status. Microsatellite instability was not different between the two groups, but p53 overexpression in HPIN-GC was marginally higher than in HPIP-GC (56.0% for HPIN-GC vs 37.0% for HPIP-GC, p=0.055). CONCLUSIONS: The prevalence of HPIN-GC was extremely low, and its clinicopathologic characteristics were similar to HPIP-GC.
